Hakan Goker

Hakan Göker, Ph. D.,

Ankara University, Faculty of Pharmacy

Department of Pharmaceutical Chemistry, Tandogan 06100, Ankara, Turkey

Office:(90)-312-2033013 or (90)-312-2033068

Fax: (90)-312-213 1081

E-mail: goker@pharmacy.ankara.edu.tr

DATE of BIRTH and PLACE : Dec 20, 1958, Merzifon

MARITAL STATUS : Married, two children

ACADEMIC QUALIFICATIONS:

1980: BS : University of Ankara, Fac. of Pharmacy

1985: Ph.D. in Pharmaceutical Chemistry, Ankara University, Fac. of Pharmacy

1987: Assistant Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry

1990: Associate Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry

1996: Professor in Ankara University, Fac. of Pharmacy, Dept. of Pharmaceutical Chemistry

CURRENT STATUS : Professor in Ankara University, Faculty of Pharmacy, Department of
Pharmaceutical Chemistry

RESEARCH INTEREST: Drug Synthesis, Benzopyran and Benzimidazole, Benzoxazin, Imidazopyridine
as hetereocyclics, Antifungal and antiaggregan activities, amidine chemistry

ACADEMIC CARIER

1981 -       Ankara University, Pharmacy Faculty
June 1987   Research Scientist, Ludwigsfahen, Germany.
June-September 1994 Research Scientist, Tokushima University, Tokushima, Japan.
August 1998 - May 1999 Research Scientist, Georgia State University, Atlanta, U.S.A.
July - September 2000,   Research Scientist, Georgia State University, Atlanta, U.S.A.
July - August 2001, Research Scientist, Georgia State University, Atlanta, U.S.A.

AWARDS:
Novartis (Pharmaceutical and Medicinal Chemistry, 2007, First winner prize)

PUBLICATIONS:
1. M.Ertan, R.Ertan, H.Göker , U.Pindur., Studies on the Synthesis of Some Flavonoid DerivativesPossessing Spasmolytic Activity V. Arch.Pharm. (Weinheim) , 320, 1132, 1987.
2. R.Ertan, H.Göker, M.Ertan, U.Pindur., Synthesis of New Annulated Flavonoid DerivativesPossessing Spasmolytic Activity VII. Arch.Pharm (Weinheim), 322, 237, 1989.
3. H.Göker, R.Ertan., Studies on the Synthesis of Some Biologically Active Flavonoid Derivatives, Die Pharmazie, 45, 734, 1990.
4. H.Göker, R.Ertan, H.Akgün, N.Yulug., Synthesis and Antifungal Activity of Some New Benzimidazole Derivatives, Arch.Pharm (Weinheim) 324, 283, 1991.
5. R.Ertan, H.Göker, M.Ertan, A.Beretz, J.P.Cazenave, M.Haag, R.Anton,Synthesis of Some FlavoneDerivatives : Potent Inhibitors Human Platelet Aggregation, Eur. J. Med. Chem, 26,735,1991.
6. H.Göker, M.Tunçbilek, G. Leoncini, E.Buzzi, M. Mazzei, Y. Rolland, R. Ertan, Synthesis and Inhibitory Activities on Platelet Aggregation of Some Flavonoid Analogues, Arznm.Forschung ,
45(1), 2, 150-155, 1995 .
7. H. Göker, C. Kus, U. Abbasoglu, Synthesis of 1,2,5(6)-Trisubstituted Benzimidazoles and Evaluation of Their Antimicrobial Activities, Arch.Pharm (Weinheim) 328, 425-430 (1995) (full text)
8. H. Göker, G. Ayhan., M. Tunçbilek, R. Ertan., G. Leoncini, R. Garzoglio., M. Mazzei. Synthesis and Antiaggregator Activity of Some New derivatives of 4H-1-benzopyran-4-one, Eur J Med
Chem, 30, 561-567, 1995. [full text]
9. H. Göker, S. Ölgen, R. Ertan, H. Akgün, S. Özbey, E. Kendi, G. Topçu. Synthesis of Some New Benzimidazole-5(6)-carboxylic Acids, J. Hetereocyclic Chem. 32, 1767-1773, 1995.
10. H. Göker, E. Tebrizli, U. Abbasoglu. Synthesis of 1,2-disubstituted Benzimidazole-5(6)-carboxamides and Evaluation of Their Antimicrobial Activity, Farmaco, 51, 53-58, 1996.
11. C. Kus, H. Göker, G. Ayhan, R. Ertan, N. Altanlar, A. Akin. Synthesis and Antimicrobial Activity of Some New Piperidinylbenzimidazoles, Farmaco, 51, 6, 413-417, 1996.
12. M. Tuncbilek, H. Goker, R. Ertan, R. Eryigit, E. Kendi, N, Altanlar. Synthesis and Antimicrobial Activity of Some New Anilino Benzimidazoles, Arch. Pharm. Pharm. Med. Chem., 330,
      372-376, 1997.
13. S. Ozbey, E. Kendi, H. Goker, R. Ertan. {2-(2-Ethoxycarbonyl)-1,4-benzodioxan-7-yl}-4H-1-benzopyran-4-one. Acta Crystallogr. C53, 1981-1983, 1997.
14. E. Kendi, S. Ozbey, M. Tuncbilek, H. Goker . 1-Benzyl-2-(2,6-dichloro-1-anilinomethyl)-1H- benzimidazole. Acta Crystallogr. C54, 854-856 ,1998.
15. H. Goker, M. Tuncbilek, G. Ayhan, N. Altanlar. Synthesis of Some New Benzimidazole Carboxamides and Evaluation of Their Antimicrobial Activity. Farmaco, 53, 415-420, 1998. [full text]
16. S.Ozbay, E. Kendi, H.Goker, M. Tuncbilek. The structure of 1-(p-fluorophenylmethyl)-2-(4-methyl-1-piperazinyl)-1H-benzimidazole hydrogen fumarate. J.Chem. Crystallogr., 28 (6),                                   461-464, 1998. [full text]
17. E.Kendi, S.Ozbay, H.Goker. 2,5-Dichloro-1-(p-chlorobenzyl)-1H-benzimidazole. Acta Crystallogr.C55, 243-245, 1999.
18. M.M. Candan, E. Kendi and H. Göker 4-Chloro-N-(p-fluorobenzyl)-2-nitroaniline. Acta Crystallogr.C55, 825, 1999.
19. H. Göker, G. A.Kilcigil, M. Tuncbilek,   C. Kus, R. Ertan, E. Kendi, S. Özbey, M. Fort, C. Garcia,and A. J. Farré. Synthesis and Antihistaminic H1-Activity of 1,2,5(6)-Trisubstituted
       Benzimidazoles. Heterocycles, 51(11), 2561-2573, 1999.

20. G. A.Kilcigil, M. Tuncbilek, N. Altanlar, H. Göker, Synthesis and antimicrobial activity of some new benzimidazolecarboxylates and carboxamides. Farmaco, 54, 562-565, 1999. [full text]

21. S. Özcan, E. Kendi, M. Tunçbilek, H. Göker, Methyl -(4-chlorobenzyl)-2-(4-methylpiperazin-1-yl)-1H-benzimidazole-5-carboxylate hemihydrate Acta Cryst. C56, 459-460, 2000.

22. S. Özden, A.M. Öztürk, H. Göker, N. Altanlar, Synthesis and Antimicrobial Activity of Some New 4-Hydroxy-2H-1,4-benzoxazin-3(4H)-ones. Farmaco 55(11-12), 715-718, 2000.[full text]
23. H. Göker , S. Süzen, C. Kus, D.W. Boykin . Synthesis of New 2-aryl-4H- 4-oxo-1-Benzopyran oxime Ethers. Hetereocyclic Communications 6, 385-390, 2000.
24. H Göker, M. Tunçbilek, S. Süzen, C. Kus, N. Altanlar, Synthesis and Antimicrobial Activity of Some New 2-Phenyl-N-substituted Carboxamido-1H-benzimidazole Derivatives, Arch. Pharm.
       Pharm. Med. Chem 334, 148-152 , 2001.[full text]
25. S. Özbey, C. Kus, H.Göker , Crystal structure of 1-Cyclopropyl-2-ethyl-5-fluoro-6-(4-methyl-piperazin -1-yl)-1H-benzimidazole,   Analytical Sciences, 17(8), 1019-1020, 2001 .[full text]
26. C. Kus, H.Göker , N. Altanlar, Synthesis and Antimicrobial Activities of 5-Fluoro-1,2,6-Trisubstituted Benzimidazole Carboxamide and Acetamide Derivatives, Arch. Pharm. Pharm. Med.
Chem, 334, 361-365, 2001 .[full text]
27. D.W. Boykin, H.Göker , Ring Cleavage of   bis-cyanosubstituted benzimidazoles by DIBAL, Hetereocyclic Communications, 7, 529-534, 2001. [full text]
28. H. Göker, C. Kus, D.W. Boykin, S. Yildiz, N. Altanlar, Synthesis of some new 2-substituted-phenyl-1H- benzimidazole-5-carbonitriles and their potent activity against Candida species. Biorg.                 Med. Chem. 10, 2589-2596, 2002. [full text]
29. C. Kus, H Göker, D.W. Boykin, Synthesis of Some New N-Isopropylamidinobenzimidazoles as potential topoisomerase inhibitors,   Hetereocyclic Communications. 8, 215-220, 2002.
30. S. Özbey, F.B. Kaynak, C. Kus, H. Göker, 2-(2,4-Dichlorophenyl)-5-fluoro-6-morpholin-4-yl-1H-benzimidazole monohydrate, Acta Cyrst. E 58, o1062-o1064, 2002. [full text]
31. M.D.Givens, C.C.Dykstra, K.V.Brock, D.A.Stringfellow, A.Kumar, C.E.Stephens, H. Göker, D.W.Boykin, Detection of inhibition Bovine Viral Diarrhea Virus by Aromatic Cationic Molecules,
    Antimicrobial Agents and Chemotherapy, 47(7), 2223-2230, 2003. [full text]
32. C.Kazak, H.Göker and S. Ide   2-Acetylphenyl 5-methylthiophene-2-carboxylate Acta Cryst., 2003. E59, o1362-o1363 [full text]
33. C. Kazak, V. Yýlmaz, H. Göker, C. Kus 1-n-Butyl-2-(4’-Fluorophenyl)-1H-benzimidazole-6-carbonitrile, Acta Cryst. 2004. E60, m819-m821, [full text]
34. S. Özden., H. Karataþ., S. Yildiz., H. Goker. Synthesis and Potent Antimicrobial Activity of Some Novel 4-(5,6-Dichloro-1H-benzimidazole-2-yl)-N-substituted benzamides, Arch. Pharm.
    Pharm. Med. Chem. 2004, 337, 556-562. [full text]
35. B. Arslan, C. Kazak, H. Göker, 2,6-Dimethyl-4H-1-benzopyran-4-one, Acta Cryst., 2004. E60, o2238-o2240. [full text]
36. S. Özbey, F.B. Kaynak., H. Göker, C. Kuþ. Synthesis and crystal structure elucidation of 1- (4-fluorobenzyl)-2-(4-cyanophenyl)-1H-benzimidazole-5-carbonitrile, J. Chem. Cryst. 34 (12),
      2004, [full text]
37. H. Göker., D. Boykin., S. Yildiz. Synthesis and Potent Antimicrobial activity of Some Novel 2-Phenyl or Methyl-4H-1-Benzopyran-4-ones carrying amidinobenzimidazoles, Bioorg. Med.
      Chem , 13, 2005, 1707-1714. [full text]
38. S. Özden., D. Atabey, S.Yildiz, H. Göker, Synthesis and Potent Antimicrobial activity of Some Novel Methyl or Ethyl 1H-Benzimidazole-5-carboxylates derivatives carrying amide or amidine
       groups,   Bioorg. Med. Chem. 13, 2005, 1587-1597. [full text]
39. H. Göker , S. Ozden, S. Yildiz, D. Boykin,   Synthesis and Potent Antibacterial Activity against MRSA of Some Novel 1,2-Disubstituted-1H-Benzimidazole-N-alkylated-5-carboxamidines,
Eur. J.Med. Chem , 40, 2005, 1062-1069.   [full text]
40. H. Göker, M. Alp,S.Yildiz, Synthesis & Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-carboxamidines, Molecules, 2005,10,1377-1386. [full text]
41. Z. Ates-Alagöz, M. Alp, C. Kus, S. Yildiz, E. Buyukbingöl, H. Göker, Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles, Arch. der.
      Pharm. 2006, 339, 74-80. [full text]
42. C. Kazak, V.T. Yilmaz, H. Göker, C. Kus, Synthesis and molecular structures of 1-n-butyl-2-(3'-chlorophenyl)-1H-benzimidazole-5-carbonitrile hemihydrate and 1-n-butyl-2-(3',4'-dimethoxy-                    phenyl)-1H-benzimidazole-5-carbonitrile, Cryst.Res.Technol. 2006, 41,528-532, [full text]
43. Ö.Ö.Güven, T. Erdogan, H.Göker, S.Yildiz, Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers, Bioorg. Med. Chem. Lett. 2007,17,
2233-2236. [full text]
44. Ö.Ö.Güven, T. Erdogan, H. Göker, S.Yildiz, Synthesis and antimicrobial activity of some novel Some Novel Furyl and benzimidazole substituted benzyl ethers, J.   Heterocyclic Chem., 2007, 44,
    731-734. [full text]
45. S. Ozden, D. Atabey, S. Yildiz, H. Göker, Synthesis, Potent anti-Staphylococcal Activity and QSARs of Some Novel 2-Anilinobenzazoles, Eur. J. Med. Chem. 2008, 43, 1390-1402.
46. M. Alp, H. Göker, R. Brun, S. Yildiz, Synthesis and antiparasitic and antifungal evaluation of 2'-Arylsubstituted-1H,1'H- [2,5']bisbenzimidazolyl-5-carboxamidines, Eur. J. Med. Chem.,2009,
      (in press)